Are environmentally friendly firms more vulnerable during the COVID-19 pandemic?

The COVID-19 pandemic has affected supply and demand to a large extent. Declining demand for firms' output has caused significant financial stress for all kinds of firms worldwide. Production that requires environmental measures usually gets constrained when firms, especially small and medium-sized firms (SMEs), have difficulty in accessing credit. Firms thus face the dilemma of whether to continue environmental behaviors or to fulfill financial commitments to suppliers, employees, and so on. As such, an empirical question is whether the economic consequences of COVID-19 vary by firms’ types and their environmental behaviors. Using 4,888 sample firms from 14 EU member states, this study finds evidence that the severity of damage caused by COVID-19 depends on firm size and whether firms invested in pollution abatement techniques. Specifically, eco-friendly firms perform better during the COVID-19 pandemic, and SMEs are less vulnerable than large firms. In particular, eco-friendly SMEs are less affected by the pandemic than conventional SMEs and large firms. These findings are probably related to the efficacy of government relief programs targeted to eco-friendly SMEs and/or the healthy financial status of these firms prior to the pandemic.publishedVersio

Import demand under price and exchange-rate uncertainties: The case of U.S. Atlantic salmon imports

This study investigates the impacts of price and exchange rate volatilities on Atlantic salmon imports in the U.S. market. We first derive an extended Rotterdam demand model, revealing how risk factors affect import demand through ‘adjusted’ prices. For example, the theoretical model shows that risk-averse importers add risk premiums as a markup for the cost of risk factors. Moreover, the trade effect of volatility variables depends on own-price elasticities and the degree of substitutability between competing products. Our empirical results reveal that U.S. salmon importers are sensitive to price and exchange rate volatilities; however, these two risk factors have differing impacts on import demand, implying the necessity (or effect) of hedging strategies.publishedVersio

ARPES insights on the metallic states of YbB6(001): E(k) dispersion, temporal changes and spatial variation

We report high resolution Angle Resolved PhotoElectron Spectroscopy (ARPES) results on the (001) cleavage surface of YbB$_{6}$, a rare-earth compound which has been recently predicted to host surface electronic states with topological character. We observe two types of well-resolved metallic states, whose Fermi contours encircle the time-reversal invariant momenta of the YbB$_{6}$(001) surface Brillouin zone, and whose full (E,$k$)-dispersion relation can be measured wholly unmasked by states from the rest of the electronic structure. Although the two-dimensional character of these metallic states is confirmed by their lack of out-of-plane dispersion, two new aspects are revealed in these experiments. Firstly, these states do not resemble two branches of opposite, linear velocity that cross at a Dirac point, but rather straightforward parabolas which terminate to high binding energy with a clear band bottom. Secondly, these states are sensitive to time-dependent changes of the YbB$_{6}$ surface under ultrahigh vacuum conditions. Adding the fact that these data from cleaved YbB$_{6}$ surfaces also display spatial variations in the electronic structure, it appears there is little in common between the theoretical expectations for an idealized YbB$_{6}$(001) crystal truncation on the one hand, and these ARPES data from real cleavage surfaces on the other.Comment: 8 pages, 4 figures (accepted in Physical Review B

Distractor-aware Event-based Tracking

Event cameras, or dynamic vision sensors, have recently achieved success from fundamental vision tasks to high-level vision researches. Due to its ability to asynchronously capture light intensity changes, event camera has an inherent advantage to capture moving objects in challenging scenarios including objects under low light, high dynamic range, or fast moving objects. Thus event camera are natural for visual object tracking. However, the current event-based trackers derived from RGB trackers simply modify the input images to event frames and still follow conventional tracking pipeline that mainly focus on object texture for target distinction. As a result, the trackers may not be robust dealing with challenging scenarios such as moving cameras and cluttered foreground. In this paper, we propose a distractor-aware event-based tracker that introduces transformer modules into Siamese network architecture (named DANet). Specifically, our model is mainly composed of a motion-aware network and a target-aware network, which simultaneously exploits both motion cues and object contours from event data, so as to discover motion objects and identify the target object by removing dynamic distractors. Our DANet can be trained in an end-to-end manner without any post-processing and can run at over 80 FPS on a single V100. We conduct comprehensive experiments on two large event tracking datasets to validate the proposed model. We demonstrate that our tracker has superior performance against the state-of-the-art trackers in terms of both accuracy and efficiency

Temporal Course of Cerebral Autoregulation in Patients With Narcolepsy Type 1: Two Case Reports

Cerebral autoregulation is the mechanism by which constant cerebral blood flow is maintained despite changes in arterial blood pressure. In the two presented cases, cerebral autoregulation was impaired in patients with narcolepsy type 1, and both venlafaxine and fluoxetine may have the potential to improve the impaired cerebral autoregulation. A relationship may exist between impaired cerebral autoregulation and neurological symptoms in patients with narcolepsy type 1

The Herbal Combination of Radix astragali, Radix angelicae sinensis, and Caulis lonicerae Regulates the Functions of Type 2 Innate Lymphocytes and Macrophages Contributing to the Resolution of Collagen-Induced Arthritis

Type 2 innate lymphocytes (ILC2s), promoting inflammation resolution, was a potential target for rheumatoid arthritis (RA) treatment. Our previous studies confirmed that R. astragali and R. angelicae sinensis could intervene in immunologic balance of T lymphocytes. C. lonicerae also have anti-inflammatory therapeutic effects. In this study, the possible molecular mechanisms of the combination of these three herbs for the functions of ILC2s and macrophages contributing to the resolution of collagen-induced arthritis (CIA) were studied. Therefore, we used R. astragali, R. angelicae sinensis, and C. lonicerae as treatment. The synovial inflammation and articular cartilage destruction were alleviated after herbal treatment. The percentages of ILC2s and Tregs increased significantly. The differentiation of Th17 cells and the secretion of IL-17 and IFN-γ significantly decreased. In addition, treatment by the combination of these three herbs could increase the level of anti-inflammatory cytokine IL-4 secreted, active the STAT6 signaling pathway, and then contribute to the transformation of M1 macrophages to M2 phenotype. The combination of the three herbs could promote inflammation resolution of synovial tissue by regulating ILC2s immune response network. The synergistic effects of three drugs were superior to the combination of R. astragali and R. angelicae sinensis or C. lonicerae alone

Single-cell analysis reveals melanocytes may promote inflammation in chronic wounds through cathepsin G

During acute wound (AW) healing, a series of proper communications will occur between different epidermal cells at precise temporal stages to restore the integrity of the skin. However, it is still unclear what variation happened in epidermal cell interaction in the chronic wound environment. To provide new insights into chronic wound healing, we reconstructed the variations in the epidermal cell-cell communication network that occur in chronic wound healing via single-cell RNA-seq (scRNA-seq) data analysis. We found that the intricate cellular and molecular interactions increased in pressure ulcer (PU) compared to AW, especially the PARs signaling pathways were significantly upregulated. It shows that the PARs signaling pathways’ main source was melanocytes and the CTSG-F2RL1 ligand-receptor pairs were its main contributor. Cathepsin G (CatG or CTSG) is a serine protease mainly with trypsin- and chymotrypsin-like specificity. It is synthesized and secreted by some immune or non-immune cells. Whereas, it has not been reported that melanocytes can synthesize and secrete the CTSG. F2R Like Trypsin Receptor 1 (F2RL1) is a member of proteinase-activated receptors (PARs) that are irreversibly activated by proteolytic cleavage and its stimulation can promote inflammation and inflammatory cell infiltration. In this study, we found that melanocytes increased in pressure ulcers, melanocytes can synthesize and secrete the CTSG and may promote inflammation in chronic wounds through CTSG-F2RL1 pairs, which may be a novel potential target and a therapeutic strategy in the treatment of chronic wounds

An atlas of DNA methylomes in porcine adipose and muscle tissues

It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from three pig breeds living within comparable environments but displaying distinct fat level. We generate 1,381 Gb of sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a genome-wide DNA methylation map as well as a gene expression map for adipose and muscle studies. The analysis shows global similarity and difference among breeds, sexes and anatomic locations, and identifies the differentially methylated regions. The differentially methylated regions in promoters are highly associated with obesity development via expression repression of both known obesity-related genes and novel genes. This comprehensive map provides a solid basis for exploring epigenetic mechanisms of adipose deposition and muscle growth

The Impact of Variational Primary Collaterals on Cerebral Autoregulation

The influence of the anterior and posterior communicating artery (ACoA and PCoA) on dynamic cerebral autoregulation (dCA) is largely unknown. In this study, we aimed to test whether substantial differences in collateral anatomy were associated with differences in dCA in two common types of stenosis according to digital subtraction angiography (DSA): either isolated basal artery and/or bilateral vertebral arteries severe stenosis/occlusion (group 1; group 1A: with bilateral PCoAs; and group 1B: without bilateral PCoAs), or isolated unilateral internal carotid artery severe stenosis/occlusion (group 2; group 2A: without ACoA and with PCoA; group 2B: with ACoA and without PCoAs; and group 2C: without both ACoA and PCoA). The dCA was calculated by transfer function analysis (a mathematical model), and was evaluated in middle cerebral artery (MCA) and/or posterior cerebral artery (PCA). Of a total of 231 non-acute phase ischemic stroke patients who received both dCA assessment and DSA in our lab between 2014 and 2017, 51 patients met inclusion criteria based on the presence or absence of ACoA or PCoA, including 21 patients in the group 1, and 30 patients in the group 2. There were no significant differences in gender, age, and mean blood pressure between group 1A and group 1B, and among group 2A, group 2B, and group 2C. In group 1, the PCA phase difference values (autoregulatory parameter) were significantly higher in the subgroup with patent PCoAs, compared to those without. In group 2, the MCA phase difference values were higher in the subgroup with patent ACoA, compared to those without. This pilot study found that the cross-flow of the ACoA/PCoA to the affected area compensates for compromised dCA in the affected area, which suggests an important role of the ACoA/PCoA in stabilizing cerebral blood flow